Vodianova has achieved considerable success as a runway, editorial and advertising campaign model. To date, Vodianova has walked in more than 175 runway shows for U.S. and European based designers' ready-to-wear and haute couture collections, has appeared in editorial spreads in fashion magazines worldwide and has completed advertising campaigns for Shiatzy Chen, Calvin Klein, Louis Vuitton, Yves Saint Laurent, L'Oréal, David Yurman, Marc Jacobs, Pepe Jeans, Diane von Fürstenberg, Chanel, Guerlain and others.

Vodianova is a founder and the president of the Naked Heart Foundation  a philanthropic organization that strives to provide a safe and inspiring environment in which to play for every child living in urban Russia.